Dr. Shyam S. Chauhan

Email ID: s_s_chauhan@hotmail.com 

Phone(O): +91-11-26594609

Academic Details: 

Positions Held: 

Awards and Honors:

AIIMS Excellence Research Award-2018, Fellow of The National Academy of Sciences, Allahabad (FNASc.)-2018, Fellow of National Academy of Medical Sciences (FAMS)-2017, Fellow of Indian Academy of Biomedical Sciences (FIABS)-2017, Prof. T.N. Pattabhiraman Oration Award of ACBI-2015, Mrs. and Dr. G.P. Talwar Oration Award of ACBI-2004, Fogarty International Research Fellowship to work as a visiting scientist at National Cancer Institute, NIH, Bethesda, MD, USA, (1999-2000), FIMSA Bursary Award-1996.

Membership of Professional Bodies:
Association of Clinical Biochemists of India, Society of Biological Chemists (India), Indian Association for Cancer Research, Indian Immunology Society, International Society for Heart Research.

Research Focus of the Lab:

Cathepsins, a heterogeneous group of lysosomal proteases are ubiquitously present in the nature. They are involved in physiological functions such as degradation and turnover of intracellular proteins, neo-vascularization, antigen presentation, pro hormone activation, sperm maturation, embryo implantation, cell growth and tissue homeostasis etc. These functions are altered in many pathological conditions including cancer and other ECM related pathologies. These proteases are overexpressed in malignancy and silencing their expression lead to: impaired pro-hormone and pro-enzyme activation, immune defects, osteoporosis, epidermal hyperplasia, abnormal bone development and dilated cardiomyopathy. These observations underscore the importance of their controlled expression for various life processes. Therefore, the major focus of my laboratory is to understand the molecular mechanism(s) responsible regulation of these proteases particularly cathepsin L and B in several malignancies including gliomas, leukemia and gall bladder carcinoma with the objective of using it as a therapeutic target. Another major focus of our laboratory is to identify the biomarkers for early detection of gall bladder and oral cancer using high-throughput genomic and proteomic approach. We are also studying the molecular mechanism underlying the upregulation of RNA binding protein hnRNPD in the pathogenesis of oral cancer. PTEN mutations are preferentially found in human glioblastoma, with reported frequencies ranging from 15% to 40%. So there is an ongoing investigation in the lab to understand the clinical significance of PTEN regulated genes in human primary glioblastoma cells in relation to p53 status and understand their potential utility as prognostic markers and therapeutic targets.

List of Publications: 

1. Arora M, Kumari S, Singh J, Chopra A, Chauhan SS. Expression pattern, regulation, and clinical significance of TOX in breast cancer. Cancer Immunol Immunother. 2020 Aug 5.
   doi: 10.1007/s00262-020-02689-3. Online ahead of print.


2. Fatima N, Ahmed SH, Chauhan SS, Mohammad O, Rehman SMF. Structural equation modelling analysis determining causal role among methyltransferases, methylation, and apoptosis during human pregnancy and abortion. Sci Rep. 2020 Jul 24;10(1):12408.
   doi: 10.1038/s41598-020-68270-1.
   PMID: 32709893


3. Mann M, Kumar S, Sharma A, Chauhan SS, Bhatla N, Kumar S, Bakhshi S, Gupta R, Kumar L. PARP-1 Inhibitor Modulate β-Catenin Signaling to Enhance Cisplatin Sensitivity in Cancer Cervix. Oncotarget. 2019 Jul 2;10(42):4262-4275. doi: 10.18632/oncotarget.27008. eCollection 2019 Jul 2.


4. Pandey G, Bakhshi S, Kumar M, Thakur B, Jain P, Kaur P, Chauhan SS. Prognostic and Therapeutic Relevance of Cathepsin B in Pediatric Acute Myeloid Leukemia. Am J Cancer Res. 2019 Dec 1;9(12):2634-2649. eCollection 2019.


5. Pandey, G., Bakhshi, S., Thakur, B., Jain, P., and Chauhan, S.S.: Prognostic significance of cathepsin L expression in pediatric acute myeloid leukemia. Leuk. Lymphoma. 59: 2175 – 2187, 2018.


6. Chauhan, S., Sen, S., Sharma, A., Kashyap, S., Tandon, R., Bajaj, M.S., Pushker, N., Vanathi, M., and Chauhan, S.S.: p16INK4a overexpression as a predictor of survival in ocular surface squamous neoplasia. Br. J. Ophthalmol. 102: 840 – 847, 2018


7. Chauhan, S., Sen, S., Sharma, A., Kashyap, S., Tandon, R., Pushker, N., Vanathi, M., and Chauhan, S.S.: Loss of pRB in Conjunctival Squamous Cell Carcinoma: A Predictor of Poor Prognosis. Appl. Immunohistochem. Mol. Morphol. 26: e70, 2018


8. Singh, N., Gupta, S., Pandey, R.M., Sahni, P., Chauhan, S.S., and Saraya, A.: Prognostic significance of plasma matrix metalloprotease-2 in pancreatic cancer patients. Indian. J. Med. Res. 146: 334 – 340, 2017


9. Rashid, S., Singh, N., Gupta, S., Rashid, S., Nalika, N., Sachdev, V., Bal, C.S., Datta, Gupta, S., Chauhan, S.S., and Saraya, A.: Progression of Chronic Pancreatitis to Pancreatic Cancer: Is There a Role of Gene Mutations as a Screening Tool. Pancreas. 47: 227- 232, 2018


10. Tiwari, V., Poudel, R.R., Khan, S.A., Mehra, S., Chauhan, S.S., and Raje, A.: Is VEGF under-expressed in Indian children with Perthes disease? Musculoskelet Surg. 102: 81- 85, 2018


11. Manchanda, M., Das, P., Gahlot, G.P.S., Singh, R., Roeb, E., Roderfeld, M., Datta, Gupta S., Saraya, A., Pandey, R.M., and Chauhan, S.S.: Cathepsin L and B as potential markers for liver fibrosis: Insights from patients and experimental models. Clin. Transl. Gastroenterol. 8(6):e99, 2017.


12. Mehra, S., Kumar, M., Manchanda, M., Singh, R., Thakur, B., Rani, N., Arava, S., Narang, R., Arya, D.S., and Chauhan, S.S.: Clinical significance of cathepsin L and cathepsin B in dilated cardiomyopathy. Mol. Cell. Biochem. 428:139 – 147, 2017


13. Kumar, M., Mehra, S., Thakar, A., Shukla, N.K., Roychoudhary, A., Sharma, M.C., Ralhan, R., and Chauhan, S.S.: End Binding 1 (EB1) overexpression in oral lesions and cancer: A biomarker of tumor progression and poor prognosis. Clin. Chim. Acta. 459: 45 – 52, 2016


14. Chaudhary, A., Kumar, V., Singh, P.K., Sharma, P., Bairagya, H.R., Kaur, P., Sharma, S., Chauhan, S.S., and Singh, T.P.: A glycoprotein from mammary gland secreted during involution promotes apoptosis: Structural and biological studies. Arch. Biochem. Biophys. 644: 72 - 80, 2018.


15. Prajapati, S.C., and Chauhan, S.S.: Human dipeptidyl peptidase III mRNA variant I and II are expressed concurrently in multiple tumor derived cell lines and translated at comparable efficiency in vitro. Mol. Biol. Rep. 43: 457 – 462, 2016.


16. Prajapati, S. C., Singh, R., and Chauhan, S. S.: Human dipeptidyl peptidase III regulates G-protein coupled receptor-dependent Ca2+ concentration in human embryonic kidney 293T cells. Biol. Chem. 397: 563-569. 2016.


17. Kumar, Y., Jain, V., Chauhan, S.S., Bharate, V., Koli, D. and Kumar, M.: Influence of different forms and materials (zirconia or titanium) of abutments in peri-implant soft-tissue healing using matrix metalloproteinase-8: A randomized pilot study. J Prosthet Dent. 2017 118:475-480.


18. Chauhan, S.S., Kaur, J., Kumar, M., Matta, A., Srivastava, G., Alyass, A., Assi, J., Leong, I., MacMillan, C., Witterick, I., Colgan, T.J., Shukla, N.K., Thakar, A., Sharma, M.C., Siu, K.W., Walfish, P.G., and Ralhan R.: Prognostic molecular signature for head and neck squamous cell carcinoma. Oncogenesis. 2015 Apr 20;4:e147. doi: 10.1038/oncsis.2015.7.


19. Kumar, M., Srivastava, G., Kaur, J., Assi, J., Alyass, A., Leong, I., MacMillan, C., Witterick, I., Shukla, N.K., Thakar, A., Duggal, R., Roychoudhury, A., Sharma, M.C., Walfish, P.G., Chauhan, S.S. and Ralhan R.: Prognostic significance of cytoplasmic S100A2 over expression in oral cancer patients. J Transl. Med., 13: 8, 2015.


20. Singh, N., Gupta, S., Pandey, R.M., Chauhan, S.S. and Saraya, A.: High levels of cell-free circulating nucleic acids in pancreatic cancer are associated with vascular encasement, metastasis and poor survival. Cancer Invest, 33:78-85, 2015.


21. Singh, R., Sharma, M.C., Sarkar, C., Singh, M. and Chauhan, S.S.: Transcription factor C/EBP-β mediates down regulation Dipeptidyl peptidase III by interleukin 6 in glioblastoma cells. FEBS J.281: 1629-1641, 2014.


22. Singh, N., Das, P., Gupta, S., Sachdev, V., Srivasatava, S., Datta Gupta, S., Pandey, R.M., Sahni, P., Chauhan, S.S. and Saraya, A.: Plasma cathepsin L: A prognostic marker for pancreatic cancer. World J Gastroenterol. 20: 17532-17540, 2014.


23. Gill, K., Nigam, L., Singh, R., Kumar, S., Subbarao, N., Chauhan, S.S., Dey, S: The Rational Design of Specific Peptide Inhibitor against p38α MAPK at Allosteric-Site: A Therapeutic Modality for HNSCC. PLoS One. 9(7):e101525, 2014.


24. Hasan, M.R., Sharma, R., Saraya, A., Chattopadhyay, T.K., DattaGupta, S., Chauhan, S.S. and Ralhan, R.: Mitogen activated protein kinase kinase kinase 3 (MEKK3) over expression is an early event in esophageal tumorigenesis and is a predictor of poor disease prognosis. BMC Cancer. 1471-2407-14-2, 2014.